Journal
JOURNAL OF NATURAL PRODUCTS
Volume 67, Issue 11, Pages 1854-1858Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np049761w
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Two new yellow pigments, farinosones A (1) and B (2), were isolated from the mycelial extract of the entomogenous fungal strain Paecilomyces farinosus RCEF 0101, together with farinosone C (3), a new metabolite derived from an early step of pyridone alkaloid biosynthesis. The structures were determined by spectroscopic means, in particular by extensive NMR experiments. Compounds 1 and 3 induced neurite outgrowth in the PC-12 cell line at concentrations of 50 muM, while compound 2 was inactive. No cytotoxicity was observed for compounds 1-3 in PC-12 cells when tested at 50 muM concentration in the MTT assay.
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