Journal
HYPERTENSION RESEARCH
Volume 27, Issue 11, Pages 813-820Publisher
NATURE PUBLISHING GROUP
DOI: 10.1291/hypres.27.813
Keywords
hypertension; type 2 diabetes; peroxisome proliferator-activated receptor-gamma coactivator-1 alpha; association study
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To investigate whether variations in the peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) are associated with essential hypertension and type 2 diabetes in a Chinese population. A case-control study design was applied in a Chinese population. Two single nucleotide polymorphisms (SNPs), +1302G > A and G482S, in the PGC-1 alpha gene were genotyped and compared between 494 unrelated Chinese subjects with essential hypertension and type 2 diabetes and 555 normal control subjects with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. These two polymorphisms were in highly significant linkage disequilibrium with each other (p < 0.0001). The frequency of the 482S allele was 42.9% in the Chinese population, which was similar to the frequency in the Japanese population (43.7%), but much higher than those of Caucasian populations (30.8% to 38.1%). There were no associations of the G482S and +1302G > A polymorphisms and haplotype combinations with essential hypertension and type 2 diabetes. In addition, no associations were found between these two polymorphisms and blood pressure. In conclusion, these results indicated that these two variations in the PGC-1a gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here.
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