Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 45, Issue 6, Pages 799-812Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2004.03.010
Keywords
nitric oxide; cGMP; acetylcholine; nitric oxide synthase; atropine; nicotine; central nervous system
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Already 30 years ago, it became apparent that there exists a relationship between acetylcholine and cGMP in the brain. Acetylcholine plays a role in a great number of processes in the brain, however, the role of cGMP in these processes is not known. A review of the data shows that, although the connection between NO-mediated cGMP synthesis and acetylcholine is firmly established, the complexities of the heterosynaptic pathways and the oligosynaptic structures involved preclude a clear definition of the role of cGMP in the functioning of acetylcholine presently. (C) 2004 Elsevier Ltd. All rights reserved.
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