Journal
IUBMB LIFE
Volume 56, Issue 11-12, Pages 643-651Publisher
WILEY
DOI: 10.1080/15216540500059640
Keywords
hexacoordinate heme; cytoglobin; neuroglobin; hemoglobin; myoglobin
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Hemoglobin and related heme proteins, generally referred to as 'globins', reversibly bind gaseous diatomic ligands (O-2, NO, and CO) to a penta-coordinate heme iron atom, the ligand filling the sixth coordination site. Over the last decade, several new globins have been reported to display a functionally-relevant hexa-coordinate heme iron atom, whose sixth coordination site is taken by an endogenous protein ligand. The reversible intramolecular hexa- to penta-coordination process at the heme-Fe atom modulates exogenous ligand binding properties of hexa- coordinate globins. Here, we review current knowledge on hexa- coordinate globins in terms of their structural and functional properties.
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