Optofluidic Fabry-Perot cavity biosensor with integrated flow-through micro-/nanochannels

An optofluidic Fabry-Perot cavity label-free biosensor with integrated flow-through micro-/nanochannels is proposed and demonstrated, which takes advantages of the large surface-to-volume ratio for analyte concentration and high detection sensitivity and built-in fluidic channels for rapid analyte delivery. The operating principle is first discussed, followed by assembly of a robust sensing system. Real-time measurements are performed to test its sensing feasibility and capability including bulk solvent change and removal/binding of molecules from/onto the internal surface of fluidic channels. The results show that this sensor provides a very promising platform for rapid, sensitive, and high-throughput biological and chemical sensing. (c) 2011 American Institute of Physics. [doi:10.1063/1.3548673]