Journal
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
Volume 26, Issue 11, Pages 761-763Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00043426-200411000-00015
Keywords
granulocyte colony-stimulating factor; stem cell mobilization; splenic rupture
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Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. The authors present a case of spontaneous splenic rupture, without splenomegaly, in a parental donor undergoing PBPC mobilization, review the literature regarding this adverse event, and explore issues regarding donor safety.
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