Journal
BASIC RESEARCH IN CARDIOLOGY
Volume 99, Issue 6, Pages 392-394Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00395-004-0483-6
Keywords
heat shock protein 27; reperfusion injury; infarct size; mouse
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Heat shock proteins (hsp) represent a group of chaperones which protects the cells against a diversity of stresses. It has been demonstrated that hsp27 is constitutively present in cells where it plays an important role in different cytoprotective processes which ultimately inhibit cell death. We investigated the response of the isolated perfused mouse heart over expressing hsp27 to the ischaemia/reperfusion injury using infarct size as an end point. Our results show for the first time that mice over expressing hsp27 (verified by Western blotting analysis) were found to be protected from lethal ischaemia/reperfusion injury compared to their negative littermates.
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