Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 21, Pages 12085-12089Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.21.12085-12089.2004
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Funding
- NCI NIH HHS [CA57973, R01 CA057973] Funding Source: Medline
- NIAID NIH HHS [N01AI40034] Funding Source: Medline
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To investigate interactions between hepatitis C virus (HCV) RNA replication complexes, a system was developed to simultaneously select different HCV subgenomic replicons within the same cell. Transcomplementation of defective replicons was not observed, suggesting an isolated and independent nature of the HCV RNA replication complex. In contrast, a high level of competition between replicons was observed, such that the presence and increased fitness of one replicon reduced the capacity of a second one to stably replicate. These results suggest that at least one factor in Huh7 cells required for HCV RNA replication is limiting and saturable.
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