Journal
APPLIED PHYSICS LETTERS
Volume 99, Issue 1, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3607292
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Funding
- National Basic Research Program of China (973 Program) [2010CB834302]
- National High Technology Research and Development Program of China (863 program) [2007AA02Z452]
- Shanghai Pujiang Program [10PJ1405600]
- program for New Century Excellent Talents (NCET) in University
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In the present study, we investigated the potential of gas-filled microbubbles as contrast agents for in-line x-ray phase-contrast imaging (PCI) in biomedical applications. When imaging parameters are optimized, the microbubbles function as microlenses that focus the incoming x-rays to form bright spots, which can significantly enhance the image contrast. Since microbubbles have been shown to be safe contrast agents in clinical ultrasonography, this contrast-enhancement procedure for PCI may have promising utility in biomedical applications, especially when the dose of radiation is a serious concern. In this study, we performed both numerical simulations and ex vivo experiments to investigate the formation of the contrast and the effectiveness of microbubbles as contrast agents in PCI. (C) 2011 American Institute of Physics. [doi:10.1063/1.3607292]
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