Journal
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
Volume -, Issue 428, Pages 114-119Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.blo.0000148783.20469.4c
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- Engineering and Physical Sciences Research Council [GR/R76431/01] Funding Source: researchfish
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Cross-linked polyethylene currently is being introduced in knee prostheses. The wear rates, wear debris, and biologic reactivity of non cross-linked, moderately cross-linked, and highly cross-linked polyethylene have been compared in multidirectional wear tests and knee simulators. Multidirectional pin-on-plate wear studies of noncross-linked, moderately cross-linked (5 Mrad), and highly cross-linked (10 Mrad) polyethylene showed a 75% reduction in wear with the highly cross-linked material under kinematics found in the hip, but only a 33% reduction under wear in kinematics representative of the knee. In knee simulator studies, with the fixed-bearing press-fit, condylar Sigma cruciate-retaining knee under high kinematic input conditions, the wear of 5 Mrad moderately cross-linked polyethylene was 13 +/- 4 mm(3) per 1 million cycles, which was lower (p < 0.05) than the wear of clinically used, gamma vacuum foil GUR 1020 polyethylene (23 +/- 6 mm(3)/1 million cycles). For the low-contact stress mobile-bearing knee, the wear of moderately cross-linked polyethylene was 2 1 mm3 per 1 million cycles, which was lower (p < 0.05) than GVF GUR 1020 polyethylene (5 2 mm3/1 million cycles). The wear debris isolated from the fixed-bearing knees showed the moderately crosslinked material had a larger percentage volume of particles smaller than 1 pm in size, compared with GVF GUR 1020 polyethylene. Direct cell culture studies of wear debris generated in sterile wear simulators using multidirectional motion showed a increase (p < 0.05) in tumor necrosis factor-alpha levels and reactivity for GUR 1050 cross-linked poly- ethylene debris compared with an equivalent volume of noncross-linked GUR 1050 polyethylene. The use of crosslinked polyethylene in the knee reduces the volumetric wear rate. However, the clinical significance of reduced fracture toughness, elevated wear in abrasive conditions, and the elevated tumor necrosis factor-alpha release from smaller more reactive particles warrant further investigation.
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