Journal
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
Volume 1, Issue 1, Pages 24-30Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpcardio0025
Keywords
dietary salt loading; hypertension; left-ventricular hypertrophy; ventricular dysfunction; ventricular fibrosis
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Excessive salt intake exacerbates hypertension and further increases left-ventricular mass in clinical essential and experimental hypertension. Additionally, a growing body of evidence strongly suggests that high dietary salt loading exerts detrimental cardiac effects independently of its hemodynamic load. the clinical evidence of cardiac structural and functional alterations associated with salt is, however, scarce. In order to explore the purported beliefs in humans, in this review we draw on our experimental studies in naturally occurring hypertension and discuss the clinical implications of the nonhemodynamic mechanisms underlying these salt-related changes.
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