Journal
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume 56, Issue 11, Pages 1423-1427Publisher
WILEY
DOI: 10.1211/0022357044661
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As part of an ongoing search for novel molecules with therapeutic potential we examined the mediator release inhibition activity of a number of indanones and their derivatives. The aldol condensation product 18 was approximately twice as potent as disodium cromoglycate as an inhibitor of compound 48/80-stimulated histamine release from rat peritoneal mast cells. The activity of this class of dimeric indanone compound is significantly higher than controls and may represent a new class of mast cell stabilizing agents. Compound 18 has been selected for further biological evaluation of its mast cell stabilization profile.
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