Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 127, Issue 3, Pages 322-325Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1111/j.1365-2141.2004.05204.x
Keywords
malignant lymphomas; molecular pathogenesis; immunodeficiency; somatic mutation; proto-oncogenes
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Funding
- NCI NIH HHS [1P01CA100265, P01 CA100265] Funding Source: Medline
- NHLBI NIH HHS [K08 HL072750, 5K08HL72750] Funding Source: Medline
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Quantitative assessment of immunogen-specific T cell responses may provide a meaningful surrogate marker of functional immunity in patients following haemopoietic stem cell transplantation (HSCT). We developed a flow-cytometric assay to quantify antigen-specific T cell immunity to influenza-A and studied the T cell response to influenza vaccination in five children, 3 21 months post-HSCT. All patients showed an increase in influenza-A-specific CD4(+) immunity following vaccination while none had a detectable IgG response to the vaccine. This assay proved sufficiently sensitive to evaluate changes in T cell memory in immunocompromised individuals and could be used to better characterize post-HSCT immune reconstitution.
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