Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 11, Pages 1873-1881Publisher
WILEY
DOI: 10.1359/JBMR.040807
Keywords
osteoclast; RANKL; secreted frizzled-related protein; Wnt
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We determined that sFRP-1 mRNA was differentially expressed by osteoblast/stromal cell lines and that sFRP-1 neutralizing antibodies and siRNA complementary to sFRP-1 coding sequence enhanced, while recombinant sFRP-1 inhibited, osteoclast formation. In studying the mechanism of action for sFRP-1, we found that sFRP-1 could bind recombinant RANKL. These results suggest potential cross-talk between Wnt and RANKL pathways.
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