Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 29, Issue 11, Pages 586-592Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2004.09.008
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Two integral components of cellular transformation are increased cellular metabolism and apoptotic resistance. Recent progress in understanding the cellular functions of core apoptotic components and of growth factor-induced apoptotic regulatory proteins has indicated that the control of cellular metabolism and apoptosis are intertwined. There is growing evidence for connections between the regulation of both cellular bioenergetics and apoptosis and, thus, it is intriguing to explore the idea that growth factor regulation of cellular metabolism can directly affect cell survival.
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