Journal
APPLIED PHYSICS LETTERS
Volume 99, Issue 25, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3669534
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Funding
- National Natural Science Foundation [10875048, 51077063]
- Research Fund for the Doctoral Program of Higher Education of China [20100142110005]
- Ministry of Education, People's Republic of China
- Australian Research Council
- CSIRO's OCE
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Room-temperature, atmospheric-pressure plasma needle treatment is used to effectively minimize the adenovirus (AdV) infectivity as quantified by the dramatic reduction of its gene expression in HEK 293A primary human embryonic kidney cells studied by green fluorescent protein imaging. The AdV titer is reduced by two orders of magnitude within only 8 min of the plasma exposure. This effect is due to longer lifetimes and higher interaction efficacy of the plasma-generated reactive species in confined space exposed to the plasma rather than thermal effects commonly utilized in pathogen inactivation. This generic approach is promising for the next-generation anti-viral treatments and imunotherapies. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3669534]
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