Journal
APPLIED PHYSICS LETTERS
Volume 98, Issue 16, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3580763
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Funding
- NIH [NIHR01EB009041]
- NSF [0644713, MH059244]
- Kavli Institute
- DFG [819/1-1]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0644713] Funding Source: National Science Foundation
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In vivo transcranial and noninvasive cavitation detection with blood-brain barrier (BBB) opening in nonhuman primates is hereby reported. The BBB in monkeys was opened transcranically using focused ultrasound (FUS) in conjunction with microbubbles. A passive cavitation detector, confocal with the FUS transducer, was used to identify and monitor the bubble behavior. During sonication, the cavitation spectrum, which was found to be region-, pressure-, and bubble-dependent, provided real-time feedback regarding the opening occurrence and its properties. These findings demonstrate feasibility of transcranial, cavitation-guided BBB opening using FUS and microbubbles in noninvasive human applications. (c) 2011 American Institute of Physics. [doi: 10.1063/1.3580763]
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