Journal
MOVEMENT DISORDERS
Volume 19, Issue 11, Pages 1348-1351Publisher
WILEY-LISS
DOI: 10.1002/mds.20191
Keywords
PET; personality; insular cortex; dopamine D-2 receptor; Parkinson's disease
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Novelty seeking is a temperament trait characterized by impulsiveness and exploratory behavior. Dopamine has been suggested to be the primary neurotransmitter modulator of novelty seeking, and in young healthy subjects, a correlation between increased novelty seeking and decreased insular cortical dopamine D-2 receptor availability has been reported. The proposed link between dopamine deficiency and reduction in novelty seeking in Parkinson's disease is controversial. The present study examined whether a link between insular D-2 receptor availability and novelty seeking can be replicated in Parkinson's disease patients. [C-11]FLB 457 positron emission tomography imaging was carried out in 28 patients with Parkinson's disease, and the data were analyzed using voxel-based statistical analysis. The results demonstrated a negative correlation between the novelty seeking score and the dopamine D-2 availability bilaterally in the insular cortex (corrected P = 0.001; r = -0.74 [right hemisphere]; r = -0.66 [left hemisphere]). The results provide further support for a relationship between novelty seeking and insular D-2 receptors. They indicate that the association is crosscultural, independent of age, and unaffected by dopaminergic degeneration. (C) 2004 Movement Disorder Society.
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