Journal
APPLIED PHYSICS LETTERS
Volume 99, Issue 13, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3636439
Keywords
bio-optics; gold; light scattering; nanomedicine; nanoparticles; nanorods; spectrophotometry; suspensions; visible spectra
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Funding
- Ente Cassa di Risparmio di Firenze
- regional board of Tuscany [POR CREO FESR 2007-2013 1.1.c]
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We demonstrate a versatile concept for the quasi simultaneous and quantitative measurement of light extinction and scattering cross section spectra of nanoparticles in a darkfield microscope. We validate this method by the analysis of an aqueous suspension of gold nanorods and comparison with both numerical simulations and standard spectrophotometry measurements. Our approach holds the promise to allow one to map the principal optical properties of nanoparticles in a biological sample with mu m spatial resolution, which is an issue of particular relevance for applications in biomedical optics such as photothermolysis and laser hyperthermia. (C) 2011 American Institute of Physics. [doi:10.1063/1.3636439]
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