Journal
APPLIED PHYSICS LETTERS
Volume 98, Issue 25, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3601917
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Funding
- National Natural Science Foundation of China [50725205, 51072031]
- Fundamental Research Fund for the Central Universities [09SSXT118]
- Scientific and Technological Development Scheme of Jilin Province [201101011]
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Ultrasensitive protein detection was realized using multiphonon Resonance Raman scattering in ZnS nanocrystals. The longitudinal optical phonon line of ZnS and its overtones, which are called multiphonon Raman lines (MRLs), were used as the Raman probe signals. MRLs have a narrow bandwidth, high stability in aqueous solution, and strong resistance to interference from surface variations. Our results show that these features allow for reliable biodetection with good selectivity and high specificity. The detection limit is about 5 fM. This Raman scattering-based methodology will greatly extend the potential applications for ZnS in the biomedical sciences. (C) 2011 American Institute of Physics. [doi:10.1063/1.3601917]
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