Journal
NEUROCHEMICAL RESEARCH
Volume 29, Issue 11, Pages 2069-2073Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-004-6880-2
Keywords
neurogenesis; dentate gyrus; hippocampus; astrocytes; intermediate filaments; glial fibrillary acidic protein; vimentin
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In response to central nervous system (CNS) injury, and more discretely so also during aging, astrocytes become reactive and increase their expression of the intermediate. lament proteins glial fibrillary acidic protein (GFAP) and vimentin. Studies of mice deficient in astrocytic intermediate. laments have provided insights into the function of reactive gliosis. Recently we demonstrated robust integration of retinal transplants (1) and increased post-traumatic synaptic regeneration (2) in GFAP(-/-) Vim(-/-) mice, suggesting that modulation of astrocyte activity affects the permissiveness of the CNS environment for regeneration. Neurogenesis in the adult mammalian CNS is restricted to essentially two regions, the hippocampus and the subventricular zone. Here, we assessed neurogenesis in the hippocampus of 18-month-old GFAP(-/-) Vim(-/-) mice. In the granular layer of the dentate gyrus, cell proliferation/survival was 34% higher and neurogenesis 36% higher in GFAP(-/-) Vim(-/-) mice than in wildtype controls. These findings suggest that the adult hippocampal neurogenesis in healthy old mice can be increased by modulating astrocyte reactivity.
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