Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 99, Issue 7, Pages 757-761Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762004000700017
Keywords
Leishmania amazonensis; Leishmania braziliensis; lapachol; isolapachol; antileishmanial activity; naphthoquinones
Categories
Ask authors/readers for more resources
The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along with soluble derivatives (potassium salt) and acetate was obtained. All the compounds were assayed against metacyclic promastigotes of two different species of Leishmania associated to tegumentar leishmaniasis. L. amazonensis and L. braziliensis. All compounds presented significant activity, being isolapachol acetate the most active against promastigotes, with IC50/24h = 1.6 +/- 0.0 mug/ml and 3.4 +/- 0.5 mug/ml for respectively, L. amazonensis and L. braziliensis. This compound was also assayed in vivo against L. amazonensis and showed to be active. Its toxicity in vitro was also established, and at concentration similar to the IC50, no toxicity was evidenced In all experiments, pentamidine isethionate was used as a reference drug. The present results reinforce the potential use of substituted hydroxyquinones and derivatives as promising antileishmanial drugs and suggest a continuing study within this class of compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available