Journal
JOURNAL OF NATURAL PRODUCTS
Volume 67, Issue 11, Pages 1804-1808Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030216p
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Funding
- NCI NIH HHS [CA17625] Funding Source: Medline
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Two new monotetrahydrofuran Annonaceous acetogenins, montacin (1), and cis-montacin (2), along with four known acetogenins, annonacin, cis-annonacin, annomontacin, and cis-annomontacin, were isolated from the seeds of Annona montana. The structures of the new isolates were elucidated by spectral and chemical methods. The new acetogenins exhibited moderate in vitro cytotoxic activity against the 1A9 human ovarian cancer cell line. Interestingly, when Ca2+ was present, compounds 1 and 2 became 3- to 10-fold more active against 1A9 cells and the PTX10 subline.
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