Journal
DRUG DELIVERY
Volume 11, Issue 6, Pages 335-340Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717540490494005
Keywords
bioadhesion; fluorescent tracer; insulin; oral delivery; polyanhydride
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Uptake of novel inherently fluorescent microspheres composed of a luminescent polyanhydride, poly[p-(carboxyethylformamido)benzoic anhydride] (PCEFB), and poly(lactide-co-glycolide) (PLGA) (2: 1, weight ratio) by the gastrointestinal tract was evaluated by fluorescent microscopy. Oral efficiency of the incorporated insulin also was determined by measuring reduction of plasma glucose levels after feeding diabetic rats with a single dose of the microspheres. We found that PCEFB/PLGA microspheres could adhere to the intestinal epithelium and traverse the absorptive cells. A large number of the spheres were observed in spleen, whereas few were detected in liver within the evaluated period of time. Apparent reduction of the plasma glucose levels was observed over a span of 6 h postfeeding. The unique properties of the delivery system such as biodegradability, bioadhesivity, and inherently luminescent characteristics render it an ideal visible tracer for monitoring oral fate of polymeric microspheres.
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