Journal
JOURNAL OF IMMUNOLOGY
Volume 173, Issue 9, Pages 5445-5450Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.9.5445
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Funding
- NCI NIH HHS [CA98731, CA58033, CA69091] Funding Source: Medline
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B7-H3 is a B7 family molecule with T cell costimulatory function in vitro. The in vivo role of B7-H3 in the stimulation of tumor immunity is unclear. We report here that expression of B7-H3 by transfection of the mouse P815 tumor line enhances its immunogenicity, leading to the regression of tumors and amplification of a tumor-specific CD8(+) CTL response in syngeneic mice. Tumor cells engineered to express B7-H3 elicit a rapid clonal expansion of P1A tumor Ag-specific CD8(+) CTL in lymphoid organs in vivo and acquire the ability to directly stimulate T cell growth, division, and development of cytolytic activity in vitro. Our results thus establish a role for B7-H3 in the costimulation of T cell immune responses in vivo.
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