Journal
JOURNAL OF NEUROSURGERY
Volume 101, Issue 5, Pages 822-825Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/jns.2004.101.5.0822
Keywords
traumatic brain injury; hematoma; atorvastatin; rat
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Funding
- NINDS NIH HHS [R01 NS40225] Funding Source: Medline
- PHS HHS [P01 42345] Funding Source: Medline
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Object. Atorvastatin, a beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor, has pleiotropic effects such as improving thrombogenic profile, promoting angiogenesis, and reducing inflammatory responses and has shown promise in enhancing neurological functional improvement and promoting neuroplasticity in animal models of traumatic brain injury (TBI), stroke, and intracranial hemorrhage. The authors tested the effect of atorvastatin on intracranial hematoma after TBI. Methods. Mate Wistar rats were subjected to controlled cortical impact, and atorvastatin (1 mg/kg) was orally administered 1 day after TBI and daily for 7 days thereafter. Rats were killed at 1, 8, and 15 days post-TBI. The temporal profile of intraparenchymal hematoma was measured on brain tissue sections by using a MicroComputer Imaging Device and light microscopy. Conclusions. Data in this study showed that intraparenchymal and intraventricular hemorrhages are present 1 day after TBI and are absorbed at 15 days after TBI. Furthermore, atorvastatin reduces the volume of intracranial hematoma 8 days after TBI.
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