Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 21, Pages 12090-12095Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.21.12090-12095.2004
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Funding
- NIAID NIH HHS [R21 AI059172] Funding Source: Medline
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The lectins DC-SIGN and DC-SIGNR can augment viral infection; however, the range of pathogens interacting with these attachment factors is incompletely defined. Here we show that DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein (GP) of Marburg virus (MARV) and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. SIGNR1, a murine DC-SIGN homologue, also enhanced infection driven by MARV and Ebola virus GP and could be targeted to assess the role of attachment factors in filovirus infection in vivo.
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