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What, if anything, is the medial temporal lobe, and how can the amygdala be part of it if there is no such thing?

Journal

NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 82, Issue 3, Pages 178-198

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2004.05.005

Keywords

recognition memory; discrimination learning; perirhinal cortex; hippocampus; basal ganglia; declarative memory

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yShould the medial temporal lobe (MTL) of primates-which includes allocortical structures such as the hippocampus, neocortical structures such as the parahippocampal cortex, and nuclear structures such as the basolateral amygdala-be considered a single thing? According to the prevailing view, here termed the reification theory, the answer is yes. According to this theory, the MTL functions as an amalgamated entity that provides the neuronal mechanisms for declarative memory; the greater the damage to the MTL or any of its components, the greater the deleterious effects on declarative memory. A countervailing view, here called the balkanization theory, holds that the various components of the MTL process and store different kinds of information. According to this theory, damage to each part of the MTL causes a unique set of behavioral deficits-some involving memory, others involving perception, and yet others involving response selection. The empirical neuropsychological evidence favors the balkanization theory, as do some new concepts in theoretical neuroanatomy. Published by Elsevier Inc.

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