Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 34, Issue 11, Pages 3115-3125Publisher
WILEY
DOI: 10.1002/eji.200324711
Keywords
T lymphocytes; antigen presentation; tolerance/suppression/anergy
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Although intercellular transfer of cell surface molecules has been observed between several cells of the immune system, the physiological relevance of this phenomenon remained obscure. Until now the transfer of molecules between antigen-presenting cells (APC) and T cells has been described as a unidirectional process from APC to T cells. However, here we show that T cells in turn donate molecules to APC, and that T cell-derived vesicles can mediate this transfer. The transferred proteins are incorporated into the APC as active molecules. Our data provide evidence that T cells use intercellular molecule transfer to mediate cell contact-dependent regulation of T cell responses via modulation of the APC.
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