Journal
AMERICAN JOURNAL OF SURGERY
Volume 188, Issue 5, Pages 553-559Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjsurg.2004.07.030
Keywords
comorbidity; infection; lung cancer; morbidity; mortality
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Background: The aim of this study was to determine the surgical risks and long-term survival in alcoholic patients undergoing resection for non-small-cell lung cancer. Methods: Nineteen resected patients comprising the alcoholic group were identified by either a Diagnostic and Statistical Manual of Mental Disorders-IV diagnosis of alcohol dependence/abuse, or an alcohol consumption of 60 oz/d or more. Alcoholic patients were compared with 37 nonalcoholic patients undergoing resection. Results: Alcoholic patients had an increase in major infectious complications (37% (7 of 19] versus 5% [2 of 37], P = 0.005), respiratory failure (42% [8 of 19] versus 5% [2 of 37], P less than or equal to 0.001), and costs ($49,526 +/- $17,525 versus $18,385 +/- $3,260, P = 0.01). Alcohol abuse was the best predictor of perioperative respiratory and infectious complications (P = 0.002, B = 2.86, odds ratio = 17.5). Stage of disease (P = 0.03. B = 1.19, hazard ratio = 3.29) was a better predictor of long-term survival. Conclusions: Alcohol abuse significantly increases the risk and Cost Of lung cancer resection. For alcoholic patients surviving the perioperative period, long-term survival appears similar to non-alcohol-abusing patients. Published by Excerpta Medica, Inc.
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