Journal
GENETICS
Volume 168, Issue 3, Pages 1557-1562Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.104.032177
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The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific Suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the Suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, Suggesting that it may act on chromatin in the early embryo.
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