Journal
PARASITE IMMUNOLOGY
Volume 26, Issue 11-12, Pages 443-454Publisher
WILEY
DOI: 10.1111/j.0141-9838.2004.00727.x
Keywords
Necator americanus; Ancylostoma duodenale; immunology; epidemiology
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Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- and IgE-dependent mechanisms, and for immunological interactions between hookworm infection and other diseases.
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