Journal
JOURNAL OF BACTERIOLOGY
Volume 186, Issue 22, Pages 7618-7625Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.186.22.7618-7625.2004
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM65216, R01 GM065216] Funding Source: Medline
Ask authors/readers for more resources
We show that for two well-characterized regulatory circuits in Escherichia coli, TWO tetracycline resistance and porin osmoregulation, the transcriptional outputs in individual cells are graded functions of the applied stimuli. These systems are therefore examples of naturally occurring regulatory circuits that exhibit continuous control of transcription. Surprisingly, however, we find that porin osmoregulation is open loop; i.e., the porin expression level does not feed back into the regulatory circuit. This mode of control is particularly interesting for an organism such as E. coli, which proliferates in diverse environments, and raises important questions regarding the biologically relevant inputs and outputs for this system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available