Journal
DEVELOPMENTAL CELL
Volume 7, Issue 5, Pages 637-651Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2004.09.002
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Funding
- NIGMS NIH HHS [GMS 40198, R37 GM040198-21] Funding Source: Medline
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Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-mitosis), a fact that has useful clinical ramifications. However, this delay is seldom permanent, and in the presence of an active SAC most cells ultimately escape mitosis and enter the next G1 as tetraploid cells. This review defines and discusses the various factors that determine how long a cell remains in mitosis when it cannot satisfy the SAC and also discusses the cell's subsequent fate.
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