Journal
STROKE
Volume 35, Issue 11, Pages 2623-2627Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.STR.0000143317.70478.b3
Keywords
Alzheimer disease; atherosclerosis; cerebral ischemia; circle of Willis
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Funding
- NIA NIH HHS [P30-AG 19610, AG-19795] Funding Source: Medline
- NINDS NIH HHS [NS-39674] Funding Source: Medline
- FDA HHS [ABG 17490] Funding Source: Medline
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A growing body of evidence suggests that vascular disease underlies Alzheimer dementia. Atherosclerotic lesions in the circle of Willis and large leptomeningeal vessels were quantified and found to correlate with Alzheimer disease (AD) clinical diagnosis and neuropathology. We hypothesize that AD pathology is the complex end result of slowly evolving vascular disease and parenchymal lesions. Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia.
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