Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 52, Issue 11, Pages 1353-1355Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.52.1353
Keywords
Dioscorea cayenensis; Dioscoreaceae; steroidal saponin; antifungal activity; 2D-NMR
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The new 26-O-beta-D-glueopyranosyl-3beta,26-dihydroxy-20,22-seco-25(R)-furost-5-en-20,22-dione-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-alpha-L-rhamnopyranosyl-(1 --> 4)-[alpha-L-rhamnopyranosyl-(1 --> 2)]-beta-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C tropicalis (MICs of 20.8, 6.25, 25 mug/ml, respectively), whereas saponins 1-3 were inactive.
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