Journal
EARLY HUMAN DEVELOPMENT
Volume 80, Issue 2, Pages 125-141Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2004.06.003
Keywords
hypoxic-ischemic brain injury; infant-current concepts cerebral palsy
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An enhanced understanding of the cellular characteristics contributing to ongoing brain injury following intrapartum hypoxia-ischemia has resulted in the implementation of targeted neuroprotective strategies in the newborn period. This review briefly covers the pathogenesis of hypoxicis-chemic injury with an emphasis on reperfusion injury; the role of magnetic resonance imaging in the detection of such injury, and focuses on potential strategies both supportive and neuroprotective to prevent ongoing injury with a specific emphasis on modest hypothermia. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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