4.6 Article

Single cell manipulation using ferromagnetic composite microtransporters

Journal

APPLIED PHYSICS LETTERS
Volume 96, Issue 4, Pages -

Publisher

AMER INST PHYSICS
DOI: 10.1063/1.3293457

Keywords

biomedical materials; cellular biophysics; composite materials; ferromagnetic materials; iron compounds; microfabrication; microfluidics; microorganisms

Funding

  1. National Science Foundation CAREER [CMMI-0745019]
  2. NSF [CBET-0828167]
  3. ARO MURI SWARMS [W911NF]
  4. Div Of Civil, Mechanical, & Manufact Inn
  5. Directorate For Engineering [0745019] Funding Source: National Science Foundation

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For biomedical applications, such as single cell manipulation, it is important to fabricate microstructures that can be powered and controlled wirelessly in fluidic environments. In this letter, we describe the construction and operation of truly micron-sized, biocompatible ferromagnetic microtransporters driven by external magnetic fields. Microtransporters were fabricated using a simple, single step fabrication method and can be produced in large numbers. We demonstrate that they can be navigated to manipulate single cells with micron-size precision without disturbing the local environment.

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