Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 52, Issue 5, Pages 1184-1189Publisher
WILEY
DOI: 10.1002/mrm.20267
Keywords
echo-planar imaging; diffusion-weighted image; diffusion tensor imaging; eddy current induced distortion
Funding
- Medical Research Council [MC_U120061309] Funding Source: researchfish
- MRC [MC_U120061309] Funding Source: UKRI
- Medical Research Council [MC_U120061309] Funding Source: Medline
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Diffusion-weighted images acquired with the echo-planar imaging technique are highly sensitive to eddy current induced geometric distortions that vary with the magnitude and direction of the diffusion sensitizing gradients. Such distortions cause misalignment of images acquired with different diffusion strengths and orientations. This in turn can result in errors when calculating maps of the apparent diffusion coefficient and diffusion tensor. Previous correction methods either require separate calibration data or only deal with low-order errors. In this study, we demonstrate a method that can correct for higher-order errors. The method relies on collecting pairs of images with diffusion sensitizing gradients reversed. This paired data are first corrected for shifts and linear distortion and then combined to cancel higher-order errors. All acquired data contribute to the final results. The method has been tested by simulation, on phantoms, on adult volunteers, and on neonatal brain examinations. Magn Reson Med 52:1184-1189, 2004. (C) 2004 Wiley-Liss, Inc.
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