Journal
JOURNAL OF FLUORESCENCE
Volume 14, Issue 6, Pages 705-710Publisher
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/B:JOFL.0000047220.92976.50
Keywords
levofloxacin; DNA; Cu2+; fluorescence
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Levofloxacin (LEV) is a fluoroquinolone antimicrobial agent. LEV also inhibits DNA synthesis and is bactericidal. The mechanisms of the interaction among LEV, DNA and Cu2+ are studied by fluorescence method. In the paper, the results show that LEV and Cu2+ can form binary complex, and also LEV and DNA can form complex mediated by Cu2+. The composition of the complex is determined. The affects to the reaction are also found.
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