Journal
PHYTOMEDICINE
Volume 11, Issue 7-8, Pages 666-672Publisher
URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2003.09.005
Keywords
antimicrobial and cytotoxic activity; IC50; minimum inhibitory concentration (MIC); prenylated flavonoids
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Antimicrobial activity of the 18 prenylated flavonoids, which were purified from live different medicinal plants, was evaluated by determination of MIC using the broth microdilution methods against four bacterial and two fungal microorganisms (Candida albicans, Saccaromyces cerevisiae, Escherichia coli, Salmonella typhimurium, Staphylococcus epidermis and S. aureus). Papyriflavonol A, kuraridin, sophoraflavanone D and sophoraisoflavanone A exhibited a good antifungal activity with strong antibacterial activity. Kuwanon C, mulberrofuran G, albanol B, kenusanone A and sophoraflavanone G showed strong antibacterial activity with 5-30 mug/ml of MICs. Morusin, sanggenon B and D, kazinol B, kurarinone, kenusanone C and isosophoranone were effective to only gram positive bacteria, and broussochalcone A was effective to C albicans. IC50 values of papyriflavonol A, kuraridin, sophoraflavanone D, sophoraisoflavanone A and broussochalcone A in HepG2 cells were 20.9, 37.8, 39.1, 22.1, and 22.0 mug/ml, respectively. These results support the use of prenylated flavonolds in Asian traditional medicine to treat microbial infection and indicate a high potential for prenylated flavonoids as antimicrobial agents as well as anti-inflammatory agents. (C) 2004 Elsevier GmbH. All rights reserved.
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