Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 11, Pages 1813-1820Publisher
WILEY
DOI: 10.1359/JBMR.040808
Keywords
tail suspension; histomorphometry; bone marrow cells; c-fos; Osterix
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We analyzed the effect of unloading by tail suspension on the anabolic action of intermittent PTH in the tibia of growing mice. Unloading alleviated the PTH-induced increase of bone formation and accelerated bone resorption, consequently reducing bone mass. Reduction of the PTH-induced anabolic actions on bone was associated with unloading, which was apparently related to suppression of c-fos mRNA expression in bone marrow.
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