Journal
MOVEMENT DISORDERS
Volume 19, Issue 11, Pages 1328-1333Publisher
WILEY
DOI: 10.1002/mds.20198
Keywords
tremor; Parkinson's disease; UPDRS; akinesia; deep brain stimulation; synchronization; oscillations
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Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation ( greater than or equal to130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD. (C) 2004 Movement Disorder Society.
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