Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 6, Issue 6, Pages 862-868Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc049900s
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A novel and highly diverse tagged triazine library incorporating a triethylene glycol-based linker was synthesized using an orthogonal combinatorial approach on the solid phase and covalently immobilized on a glass substrate as a small molecule microarray (SMM). The SMM was screened with a fluorophore-conjugated human IgG, and 4 novel binders from a library of 2688 compounds were identified from the fully spatially addressable array without the need for compound decoding. Using surface plasmon resonance (SPR) analysis, binding seen on the array was confirmed, and a binding constant as low as K-d = 2.02 x 10(-6) M was measured.
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