Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 25, Issue 11, Pages 584-591Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2004.09.001
Keywords
-
Categories
Ask authors/readers for more resources
Following the loss of myelin from axons in multiple sclerosis, some axons recover the ability to conduct impulses despite the absence of an insulating sheath, providing a basis for remission of clinical deficits. By contrast, other axons degenerate and contribute to non-remitting clinical deficits and, thus, disability. Investigations using laboratory models of multiple sclerosis indicate that altered expression of two distinct isoforms of Na+ channels underlies these two processes, and the study of human tissue reveals similar changes in multiple sclerosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available