4.4 Article

A simplified green chemistry approach to the Biginelli reaction using 'Grindstone Chemistry'

Journal

TETRAHEDRON LETTERS
Volume 45, Issue 45, Pages 8351-8353

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.09.064

Keywords

tetrahydropyrimidinone; reaction by grinding; solvent-free reaction; p-TSA as an acid catalyst

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Grindstone Chemistry-a greatly evolved version of Toda's method of grinding solids together for solvent-free chemical reactions-has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones. (C) 2004 Published by Elsevier Ltd.

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