Journal
APPLIED PHYSICS LETTERS
Volume 96, Issue 21, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3431628
Keywords
DNA; molecular biophysics; radiation pressure; surface enhanced Raman scattering
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Funding
- Fundacio Cellex Barcelona, Spanish Ministry of Science and Innovation [MICINN FIS2008-00114]
- ICREA Funding Source: Custom
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Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule. (C) 2010 American Institute of Physics. [doi:10.1063/1.3431628]
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