Journal
APPLIED PHYSICS LETTERS
Volume 96, Issue 13, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3293447
Keywords
biomedical equipment; biosensors; diseases; DNA; electrochemical sensors; electrochemistry; Fourier transform spectra; gold; infrared spectra; molecular biophysics; nanobiotechnology; nanostructured materials; particle size; patient diagnosis; scanning electron microscopy; thin films; voltammetry (chemical analysis); X-ray diffraction; zirconium compounds
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Funding
- DST
- DBT
- CSIR, India
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Nanostructured zirconium oxide (ZrO2) film (particle size similar to 35 nm), electrochemically deposited onto gold(Au) surface, has been used to immobilize 21-mer oligonucleotide probe (ssDNA) specific to Mycobacterium tuberculosis by utilizing affinity between oxygen atom of phosphoric group and zirconium to fabricate DNA biosensor. This DNA-ZrO2/Au bioelectrode, characterized using x-ray diffraction, Fourier transform infrared spectroscopy, cyclic voltammetry, and scanning electron microscopy techniques, can be used for early and rapid diagnosis of M. tuberculosis with detection limit of 0.065 ng/mu L within 60s.
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