Journal
FEMS YEAST RESEARCH
Volume 5, Issue 2, Pages 133-140Publisher
WILEY-BLACKWELL
DOI: 10.1016/j.femsyr.2004.05.001
Keywords
Saccharomyces cerevisiae; life span; stress response; cell death; mitochondrial autophagy
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UTH1 is a yeast aging gene that has been identified on the basis of stress resistance and longer life span of mutants. It was also shown to participate in mitochondrial biogenesis. The absence of Uth1p was found to trigger resistance to autophagy induced by rapamycin. Uth1p is therefore the first mitochondrial protein proven to be required for the autophagic degradation of mitochondria. Since this protein is also involved in yeast cell death induced by heterologous expression of the pro-apoptotic protein Bax, the results are discussed in the light of evidence suggesting a co-regulation of apoptosis and autophagy in mammalian cells. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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