Journal
NEUROSCIENCE LETTERS
Volume 370, Issue 1, Pages 45-50Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.neulet.2004.07.063
Keywords
four-vessel occlusion model; global brain ischemia; glutathione; hippocampus; antioxidant
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Different glutathione analogues have potential to maintain or increase tissue glutathione level and to scavenge the reactive oxygen species. We designed and synthesized a novel non-toxic glutathione analogue, named UPF1, which possessed 60-fold higher hydroxyl radical scavenger efficiency in vitro. compared with glutathione itself, and investigated the effects of UPF1 on a four-vessel occlusion model of rats. The UPF1 was administered via the jugular vein in two separate experiments at two time points: 20 min before global brain ischemia and immediately before reperfusion. In both cases the number of pyramidal cells surviving in the subfield of CA 1 at the dorsal hippocampus in the UPF1-treated groups of rats was twice as high as in the vehicle group. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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